I don’t use it as a primary, but for me it’s been fine for some one-off tools.

My PC is the same build and I run Kinoite (also KDE). The only major issue I ran into was figuring out how to get a Windows VM up and running for work stuff, but I eventually got it and now that’s working smoothly, too.

The majority of what most people run is available as a Flatpak container, but there’s also rpm-ostree if you want to install packages, which functions similarly to dnf. And you still have rpm if you want to install something manually.

As far as AMD driver support goes, everything’s been working great. Can’t say how it compares to base Fedora, though, but it’s probably similar.